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Pathogenic mechanisms -
datadescrizionesizeautore documento 
04.08.26A framework for cross-species data integration, model sensitivity analysis and target prioritisation in Huntington’s disease using bionetworks32 kBanonymousapplication/msword
04.08.26Huntington’s disease and its therapeutic target genes: a global functional profile based on the HD research crossroads database32 kBanonymousapplication/msword
04.08.26HDAC4 interacts with Huntingtin and HDAC4 reduction decreases cytoplamsic aggregation and rescues synaptic dysfunction in HD mouse models32 kBanonymousapplication/msword
04.08.26The role of N-terminal phosphorylation in Huntingtin´s oligomerization, aggregation and toxicity32 kBanonymousapplication/msword
04.08.26Long-term alterations in dendritic spine stability in Huntington Disease: Mechanisms underlying learning deficits in Huntington Disease?32 kBanonymousapplication/msword
04.08.26CTCF in Huntington’s Disease32 kBanonymousapplication/msword
04.08.26Caspase-6 does not contribute to the proteolysis of mutant Huntingtin in the HDHQ150 knock-in mouse model of Huntington's Disease32 kBanonymousapplication/msword
04.08.26Huntingtin mediates anxiety/depression-related behaviors in mouse through BDNF transport and hippocampal neurogenesis32 kBanonymousapplication/msword
04.08.26Analysis of Huntingtin protein fragments in post mortem human Huntington's Disease brain tissue32 kBanonymousapplication/msword
04.08.26AMPK activation alleviates phenotypes associated to the early phases of mutant polyQ cytoxicity32 kBanonymousapplication/msword
04.08.26Systematic interactome mapping: understanding the molecular principles of neurodegenerative diseases32 kBanonymousapplication/msword
04.08.26CAG profiling in R6/1 89Q indicates early and progressive expansion in critical neuronal populations and expansion and changes in surrounding glial cell populations32 kBanonymousapplication/msword
04.08.26Genotoxic stress in fibroblasts and mesenchymal stem cells isolated from miniature pigs transgenic for n-terminal part of mutated human huntingtin32 kBanonymousapplication/msword
04.08.26Collapsin response mediator protein 4 downregulates aggregation and toxicity of mutant huntingtin32 kBanonymousapplication/msword
04.08.26Differential sensitivity of aggregate markers in HdhQ150 and YAC128 HD mouse models32 kBanonymousapplication/msword
04.08.26Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation32 kBanonymousapplication/msword
04.08.26Does a peripheral immune response influence muscle pathology in Huntington’s Disease?32 kBanonymousapplication/msword
04.08.26Immune dysfunction in HD human myeloid cells is caused by NFkB pathway dysregulation and is reversed by lowering HTT levels32 kBanonymousapplication/msword
04.08.26Hyperdopaminergic status in Huntington's Disease32 kBanonymousapplication/msword
04.08.26Decreased expression and reduced translocation to the sarcolemma of the insulin-sensitive glucose transporter GLUT4 in skeletal muscle of R6/2 mice32 kBanonymousapplication/msword
04.08.26Dysfunctional dopaminergic neurones and biphasic activitydependent dopamine release in mouse models of Huntington’s Disease32 kBanonymousapplication/msword
04.08.26Glucose metabolism is reduced in Huntington Disease: in-vivo and in-vitro evidence32 kBanonymousapplication/msword
04.08.26Lactate metabolism in the Huntington's Disease mouse model R6/232 kBanonymousapplication/msword
04.08.26Increased glucose uptake in white adipose tissue of R6/2 mice due to changes in expression and translocation of glucose transporter 4 (GLUT4)32 kBanonymousapplication/msword
04.08.26Deletion of mutant Huntingtin expression in Sim1 neurons in the BACHD mouse model of Huntington's Disease32 kBanonymousapplication/msword
04.08.26Copy number variation of the neuronal glucose transporter 3 and age of onset in Huntington’s Disease32 kBanonymousapplication/msword
04.08.26Expression of mutant Huntingtin in leptin receptorexpressing neurons does not influence the metabolic phenotype and psychiatric-like features in Huntington’s Disease32 kBanonymousapplication/msword
04.08.26Sleep and EEG abnormalities in Huntington’s Disease mice32 kBanonymousapplication/msword
04.08.26Components of the translational machinery modify toxicity in models of Huntington’s Disease32 kBanonymousapplication/msword
04.08.26Neural mechanisms underlying the dysfunction of the methamphetamine-sensitive circadian oscillator (MASCO) in a mouse model of Huntington’s Disease32 kBanonymousapplication/msword
04.08.26Voluntary exercise improves circadian function in a mouse model of Huntington’s Disease32 kBanonymousapplication/msword

Folder contiene 31 documents.