Wolfson Lecture Theatre
National Hospital for Neurology and Neurosurgery
Queen Square – London


Programme

9.30 a.m.
Coffee/Tea:
Available outside the Wolfson Lecture Theatre

10:00 - 10:05
INTRODUCTION
Allan Tobin, High Q Foundation

10:05
Why we Need Biomarkers in Huntington’s Disease
Sarah Tabrizi, IoN

10:10
Why Biomarkers Are Also Important For Animal Models of Huntington’s Disease
Gill Bates, Guy’s Hospital

10:10 – 10:30
Section on Biomarker Research in Animal Models of Huntington’s Disease

10:10 - 10:20
A source of biomarkers for the early phases of neuronal cytotoxity in HD
Christian Neri, Department of Genomic Biology, Inserm, Paris

10:20 – 10:30
Biomarkers in animal models of HD
Emmanuel Brouillet, Neuronal Death Group, Orsay, France

10:30 – 10:40
Altered endocytosis in HD transgenic mice
Claus Zabel, Institute of Genetics, Berlin

10:40 – 10:50
Behavioral abnormalities precede polQ recruitment sites and aggregates in rats transgenic for HD
Hoa-Nguyen, Tübingen, Germany

10:50 – 11:00
Biomarkers Research in Both HD Patients And Animal Models
Elaine Holmes, Imperial College, London

11:10 – 11:20
Disintegration of the sleep/wake cycle and circadian timing in HD
Jenny Morton, Cambridge

11:20 – 11:30
Endoplasmic teticulum stress sensitizes the ubiquitin/proteasome system
Nico Dantuma, Karolinska Institute, Sweden

11:30- 11:40
Neuronal induction of LMP2 and LMP7 immunoproteasome subunits in HD
Jose Lucas, Madrid, Spain

11:40 – 11:50
BDNF levels and polymorphism regulate the age of onset and severity of motor dysfunction in Huntington’s disease
Jordi Alberch, University of Barcelona

11:50-12:00 noon
Levels of orexin – a potential biomarker for Huntington’s disease?
Asa Peterson, Lund, Sweden

12:00 – 12:10
David Rubinszstein, Cambridge, UK

12:10 – 12:20
Lesley Jones, Cardiff, Wales

12:20 –12:30
Human Studies of Biomarkers in Huntington’s Disease
David Grainger, Cambridge University

12:30 – 12:40
Alexander Durr, Paris, France

12:40 – 12:50
Etienne Regulier, Lausanne, Switzerland

13:00-14:00
Buffet Lunch
Old Board Room, NHNN

14:00 – 14:10
Robyn Lindner, Discovery Project Leader, Proteome Systems Ltd.

14:10 – 14:20
Graham Jackson, MRC Prion Unit, London

14:20 – 14:30
Muscle alterations in HD patients and R6/2 mice
Bernhard Landwehrmeyer, Ulm, Germany

14:30 –14:40
Clinical,geneticandmolecular genetic investigations of PolyQdisordersandrelated
neurodegenrative diseases
Liz Hasholt, Copenhagen, Denmark

14:40 – 14:50
Pattern of beta-amyloid peptides in Cerebrospinal Fluid of Patients with Huntington´s disease
Marcus Otto, Goettingen, Germany

14:50 – 15:00
Saccadic deficits in pre-symptomatic carriers of the Huntington's disease gene
Charlotte Golding Imperial College

15:00 – 15:10
Hand Tapping in HD
Roger Barker, Cambridge University

15:10 – 15:20
Saccades: a biomarker for Huntington’s disease?
Andrew Michell, Cambridge University

15:20 – 15:30
Activity of Peripheral A2A receptor in HD: a study in presymptomatic and symptomatic HD subjects and in patients with other neurodegenerative disorders
Alessia Tarditi, University of Milan

15.30 – 15.40
Gene expression in mouse and human HD skeletal muscle
Andy Strand, Fred Hutchison Cancer Centre, Seattle

15:40 – 16:10
Coffee/Tea Break
Outside the Wolfson Lecture Theatre

16:10 – 19:00
Open Forum for Discussion

20:00 – 23.30
Dinner at Cigala’s
54 Lambs Conduit Street
WC1N 3LW
Tel: 0207 405 1717