Sat 29.01.05

13:00 - 14:00
Welcome reception an light business lunch served in the
conference room, Aquis Grana City Hotel Aachen
14:00 - 16:00
A. Challenges in designing neuroprotection trials for HD
In this section general problems and challenges for HD
neuroprotection trials will be discussed
14:00 - 14:30
A brief history of HD neuroprotection trials and the
lessons gained grom it (Berry Kremer)
14:40 - 15:10
Current outcome measures: clinical, imaging and
biomarker approaches (Bernhard Landwehrmeyer)
15:20 - 15:50
New approaches to design clinical trials: introduction to
adaptive study designs (Wilhelm Gaus)
16:00 - 16:20
Coffeebreak
16:20 - 18:00
B. How to select the favourite drug
16:20 - 17:30
What mechanisms to go for?
In this section supporters of any particular mechanism
mentioned will defend theri favourite mechanism and
list the possible drugs readily available for future trials
(structured discussion)

• NMDA receptor antagonists
• Mitochondrial boosters
• Free radical scavengers
• Aggragation inhibitors
• HDAC inhibitors
• Dopamine antagonists
• Adenosine 2A antagonists
• Growth factors
• Fatty acids
• What else?

(for proponents to subscribe to one of the mechanisms mentioned)
17:30 - 18:00
Large scale systematic screening (Collin Hovinga for SET-HD)
- Defining criteria for ideal drug data
20:00
Dinner at Restaurant Elisenbrunnen, Aachen

Sun 30.01.05

9:00 - 10:00
Large scale systematic screening (continued) (Collin Hovinga for SET-HD)
- Critical assessment of the list of drugs with effects on HD in human or disease models
- The SET-HD drug reviews -> How far are we? What is missing?
10:00 - 12:00
C. The next steps (structured discussion)
B. Kremer und C. Kosinski
10:00 - 10:15
Necessity for further preclinical testing?
Recommendations?
10:15 - 10:30
Are we ready for a recommendation of clinical trials?
10:30 - 10:45
Coffeebreak
10:45 - 11:00
Which clinical trial type?
11:00 - 11:15
Which drugs?
11:15 - 11:30
What are possible financial resources?
11:30 - 11:45
Defining aims for the next meeting
11:45 - 12:00
How to split up work and organisation of next face to
face meeting
12:00 - 13:00
Light business lunch served in the conference room

our working group meeting on the 29./30.01.2004 takes place at the Aquis-Grana City Hotel in Aachen which is situated in the very center of the town. In the attachments you will find information on the location and how to reach the hotel by car, bus, or train.
We have made single room reservations for all participants who need accomodation. If you need any special service you can either contact me or contact the hotel directly. You find all relevant information on their webpage: http://www.hotel-aquisgrana.de/english/index.html

Please let me know how you are planning to come to Aachen and when your trains of flights are arriving and leaving. I might then be able to arrange a pickup for you.

We are very pleased about some additional guests who we invited to our working group and who manage to come. These are Collin Hovinga, a neuropharmacologist from Miami, who is involved actively (and enthusiastically) in preparation of the SET-HD drug reviews. And there will be Wilhelm Gaus who most of you know already from the Euro HD network meeting in Madrid and who will bring in his expertise in statistical planning of clinical trials. Please find the complete list of participants further below.

I am very optimistic that with the input of all of you we can make this an effective and successful meeting.

If you have any further comment or suggestion to make please do not hesitate to contact me.

I wish you all a Merry Christmas time with your families and a happy new year.

Christoph Kosinski

Name                           First name
Manku                      Mehar
Landwehrmeyer          Bernhard
Garcia de Yebenes      Justo
Rissling                     Ida
Fischer                     Wilhelm
Hovinga                    Collin
Squitieri                    Ferdinando
Khan-Boluki               Jasmin
Kremer                      Berry
Vandenberghe            Wim
Gaus                        Wilhelm
de Michele                 Guiseppe
Ferreira                     Joaquim
Harjes                       Phoebe
Andrich                     Jürgen

without room reservation
Kosinski                     Christoph
Milkereit                     Eva
Lange                        Herwig